The event will put on show 600 emerging and celebrated designers and retailers, with over 100 sessions and events scheduled throughout fashion week.
Other events will include makeup masterclasses, an unsigned model search by Bella, a pop up store for Trading Blak, and a runway showing of upcycled vintage wear.
Venues to host events range from the Queen Victoria Market's Dairy Hall and the State Library, to Emporium Melbourne and the iconic Melbourne Meat Market plus more.
Lord Mayor of Melbourne, Sally Capp, described the major event as a showstopping celebration of brilliant creatives and local designers, and added:
“A key element of Melbourne Fashion Week is its runway-to-retail focus – you can walk out of an event and into a local store and buy a fabulous outfit while supporting Melbourne businesses.”
As well as supporting local jobs, the Lord Mayor said the city was benefiting financially, with its impact on the economy increasing from $4m in 2015 to $41.7m last year.
Local businesses such as printing services also benefit from fashion week events which are advertised widely through flyer and brochure printing campaigns. At past events, a programme known as Drink and Dine has also boosted bookings at city bars and restaurants. Melbourne Fashion Week will be held from October 10-16.